FIBRINOLYTIC ACTIVITY OF HEMOLYTIC STREPTOCOCCI. THE DEVELOPMENT OF RESISTANCE TO FIBRINOLYSIS FOLLOWING ACUTE HEMOLYTIC STREPTOCOCCUS INFECTIONS

The Fibrinolytic Activity of Hemolytic Streptococci

Broth cultures of hemolytic streptococci derived from patients are capable of rapidly liquefying normal human fibrin clot. The active fibrinolytic principle is also contained in sterile, cell-free filtrates of broth cultures. The degree of activity of filtrates parallels the activity of whole broth cultures sufficiently closely to indicate that large amounts of the fibrinolytic substance are fr...

Biochemical Studies on the Fibrinolytic Activity of Hemolytic Streptococci

The fibrinolysin of hemolytic streptococci exerts no hydrolytic action upon casein, gelatin, or peptone. The action on solid human fibrin is characterized by a small and gradual increase in the amino nitrogen content of the solution. The specific and special enzymatic action of fibrinolysin is contrasted with trypsin and with streptococcal peptase (4). Solutions of human fibrinogen, after brief...

Studies on Hemolytic Streptococci: II. Streptococcus pyogenes.

The Conversion of Hemolytic Streptococci to Non-hemolytic Forms

From one strain of hemolytic streptococcus three forms were isolated, which produced three different degrees of hemolysis on the surface of blood agar in the presence of oxygen. The original form was moderately hemolytic; the glossy variant was more hemolytic than the original form; and the third form, obtained by passing the original culture through mice, was non-hemolytic. Under anaerobic con...

Biochemical Studies on the Fibrinolytic Activity of Hemolytic Streptococci I. Isolation and Characterization of Fibrinolysin

The fibrinolytic activity of hemolytic streptococci designates the capacity of cultures of the organisms to liquefy rapidly human fibrin clot (1). The lyric action is referable to the presence in the culture of an extracellular substance, characteristically elaborated by those strains of hemolytic streptococci which are derived from patients suffering with acute streptococcus infections. Invest...